Hypoxia Resources

Hypoxia is a condition marked by an insufficient supply of oxygen to the cells and tissues of the body. The Respiratory Care NetWork offers the following information and resources about hypoxia.


  1. 1. Brain During Effort: Effects of Hypoxia with Respiratory Patients (NEUROX)
  2. Brain oxygenation is determined by the product of CaO2 and the cerebral blood flow(CBF; the modification of one or the other can affect the neuronal O2availability. Besides the effect of PaO2, the CBF is also regulated by thePaCO2. During effort in state of hypoxia, the drop of the PaO2 associated to a potential decrease of the PaCO2 and therefore of the CBF, can create an important dizziness between the demand and the supply of cerebral O2.
  3. 2. Intermittent Hypoxia-Induced Cardiovascular Remodeling Is Reversed by Normoxia in a Mouse Model of Sleep Apnea
  4. Background Intermittent hypoxia (IH) is the principal injurious factor involved in the cardiovascular morbidity and mortality associated with OSA. The gold standard for treatment is CPAP, which eliminates IH and appears to reduce cardiovascular risk. There is no experimental evidence on the reversibility of cardiovascular remodeling after IH withdrawal. The objective of the present study is to assess the reversibility of early cardiovascular structural remodeling induced by IH after resumption of normoxic breathing in a novel recovery animal model mimicking OSA treatment.
  5. 3. Effects of hypoxia on the brain: Neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea

  6. Hypoxia damages multiple organ systems, especially those with high-oxygen utilization, such as the central nervous system. The purpose of this study was to compare the neuropathological and neuropsychological effects of hypoxia in patients with either carbon monoxide poisoning or obstructive sleep apnea.
  7. 4. Hypoxia induces glucose uptake and metabolism of adipose-derived stem cells
  8. Galectin-3 (Gal-3) is a β-galactoside-binding lectin, which is important in inflammation, fibrosis, and heart failure. The present study aimed to investigate the role and mechanism of Gal-3 in hypoxia-induced pulmonary arterial hypertension (PAH). Male C57BL/6J and Gal‑3‑/‑ mice were exposed to hypoxia, then the right ventricular systolic pressure (RVSP) and Fulton's index were measured, and Gal‑3mRNA and protein expression in the pulmonary arteries was analyzed by reverse transcription‑quantitative polymerase chain reaction and western blotting.
  9. 5. Immunoexpression of GADD45β in the myocardium of newborns experiencing perinatal hypoxia
  10. Among the several organs affected by perinatal hypoxia, the heart plays a central role, with cell death caused mainly by apoptosis. One of the biomarkers most often linked to hypoxia-derived apoptosis of cardiomyocytes in animals is Gadd45β. From the published literature, Gadd45β is proposed as a biomarker of hypoxia-induced lesion in cardiomyocytes, both in vitro, as well as in animal models.
  11. 6. Concordance between hypoxic challenge testing and predictive equations for hypoxic flight assessment in chronic obstructive pulmonary disease patients prior to air travel
  12. Patients with chronic pulmonary diseases are at increased risk of hypoxemia when traveling by air. Screening guidelines, predictive equations based on ground level measurements, and altitude simulation laboratory procedures have been recommended for determining risk but have not been rigorously evaluated and compared. Therefore, we aimed to explore the correlation and concordance between hypoxic challenge testing and predictive equations for assessment and prediction of in-flight hypoxia in chronic obstructive pulmonary disease patients prior to air travel.
  13. 7. Signs and Symptoms of Chest Diseases: Diffuse Alveolar Hemorrhage Due to K2 Inhalation
  14. Synthetic cannabinoid receptor agonists (SCRAs), often called K2 or spice, are common drugs of abuse. Reported toxic effects of SCRAs are diverse. Diffuse alveolar hemorrhage (DAH) due to SCRA inhalation has been described albeit very rarely.
  15. 8. Impact of hypoxia inducible factors on estrogen receptor expression in breast cancer cells
  16. In women breast cancer is still the most commonly diagnosed cancer. This type of cancer is classified as a hormone-dependent tumor. Estrogen receptor (ER) expression and functional status contribute to breast cancer development and progression. Another important factor associated with cancer is hypoxia, which is defined as the state of reduced oxygen availability in tissues. Intratumoral hypoxia results in the activation of the hypoxia inducible factors (HIFs).
  17. 9. Hypoxia induces glucose uptake and metabolism of adipose‑derived stem cells.