- I did not get a photo of the poster announcing the lecture, so I felt obliged to tweet the title.
- So acid filtrate, filtrate flow rate, and filtrate protease activity all activate the channel while Na and Cl inhibit its activity.
- Some of the structural stuff can be found on the ENaC wikipedia page:
- — Pascale Lane (@PHLane)Mon, Mar 30 2015 19:54:38Eliminating this cleaved area from the molecule further activates ENaC. Actually an inhibitory subunit that proteases chop out. #Gottschalk
- So a portion of one subunit inhibits activity; only when it is cleaved out can sodium be avidly retained.
- Interesting! Children with nephrotic syndrome usually begin to diurese before their serum albumin recovers, so we know that there is some other drive to Na retention. Sounds like this is it.
- Liddle's syndrome is an activating mutation in ENaC in which patients avidly retain Na regardless of intake, resulting in kaliuresis (potassium loss) and hypertension.
- Most of these variants involve the inhibitory portion of the structure, so its activity increases.
2015 Gottschalk Award Lecture
The distinguished lectureship of the American Physiological Society Renal Section was presented on March 30 by Dr. Tom Kleyman.
byPascale Lane761 Views