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Mon, Oct 17 2011 07:23:37

Boron-containing Drugs

  1. MatToddChem
    Talk about discovery of Scynexis compound SCYX-7158 for HAT #ectmih http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001151
    MatToddChem
    Mon, Oct 03 2011 09:51:18
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  2. MatToddChem
    Not that many drugs with boron in, I'm guessing? #ectmih
    MatToddChem
    Mon, Oct 03 2011 09:52:31
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  3. Chembl
    @MatToddChem Very few - Bortezomib (Velcade) is one that springs to mind. More discussion here http://pipeline.corante.com/archives/2004/04/19/odd_elements_in_drugs.php
    Chembl
    Mon, Oct 03 2011 10:00:42
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  4. MatToddChem
    @Chembl Interesting. Wonder what it's a bioisostere for? Tetrahedral peptide hydrolysis intermediate? Phosphate? Mech of SCYX-7158 unknown.
    MatToddChem
    Mon, Oct 03 2011 10:05:31
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  5. Chembl
    @MatToddChem As far as I know, most previous use has been in the context of protease inhibitors.
    Chembl
    Mon, Oct 03 2011 10:36:23
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  6. MatToddChem
    3.5 years and $15 million to take 1st hit to CTA filing for SCYX-7158. Lots of partners. #ectmih
    MatToddChem
    Mon, Oct 03 2011 09:54:48
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  7. MatToddChem
    Only 2 methyls and one fluorine different from hit to filed lead! SCYX-7158 #ectmih
    MatToddChem
    Mon, Oct 03 2011 09:55:32
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  8. MatToddChem
    SCYX-7158 has only micromolar in vitro power - reminds you that potency is not everything. #ectmih
    MatToddChem
    Mon, Oct 03 2011 09:56:50
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