Health

ESMO 2012: Abraxane in Pancreatic Cancer

A standing room audience at the 2012 European Society for Medical Oncology Congress in Vienna listened to a Celgene sponsored satellite symposia on Pancreatic Cancer.

  1. Pancreatic Cancer: Making an Impact through Innovation
  2. The symposium featured four leading pancreatic cancer experts: Margaret Tempero MD (University of California San Francisco), Michel Ducreux MD PhD (Institut Gustave Roussy), Manuel Hidalgo MD PhD (Universidad CEU San Pablo, Madrid) and Werner Scheithauser MD, (Medical University of Vienna) 
  3. Abraxane Phase 3 Pancreatic Trial is likely to be positive
  4. While none  of the distinguished thought leaders said it directly, their palpable excitement and enthusiasm about nab-paclitaxel (Abraxane) and frequent mentions of changes in the standard of care suggests that the phase 3 trial results, expected in the very near future, will be positive. The fair balanced review of the preclinical and clinical data for nab-paclitaxel showed clear efficacy, and no data was presented that suggested otherwise. However, we will not know for sure how effective abraxane is in pancreatic cancer until the phase 3 trial results are reported, which Celgene have said will be in Q4, 2012 or Q1, 2013.
  5. Some of the key messages from the session were shared on Twitter shortly afterwards:
  6. Heading off to listen to Margaret Tempero on pancreatic cancer soon; should be an update on Abraxane, hopefully some biology too #esmo12
  7. Tempero opened pancreatic session with "We are on the verge of some very exciting developments in pancreatic cancer" #esmo12
  8. Tempero: possibility of early detection of pancreatic ducal adenocarcinoma would be transformative #esmo12
  9. While efficacy of FOLFIRINOX over gemcitabine is not in doubt, experts clearly not wowed by AE's "quite toxic" diarrhea is disliked #esmo12
  10. But in a nutshell, as we understand the biology of pan can, predictive markers are found = better way to select Tx for pats #esmo12
  11. Selecting patients for Tx in pancreatic cancer has so far been unimaginable - in the future it will be commonplace methinks #esmo12
  12. Scheithauer discussed how pancreatic cancer has multiple molecular aberrations, Hidalgo abt which ones are potentially impt #esmo12
  13. Ducreux: "Even the best regimen of RT and CT is not known" ... sums up the scorched earth that has been pancreatic cancer #esmo12
  14. Much of last 10 years have been wasted in pan cancer arguing abt 5FU vs Gem vs Gem combos. V little improved MOS beyond 6-8 months #esmo12
  15. Michel Ducreux (Institut Gustave Roussy) GEM+nab-paclitaxel va GEN ph 3 trial "we will have the results very soon" #esmo12
  16. Manuel Hidalgo (Madrid): "in a few weeks" we will know the results" of nab-paclitaxel + gemcitabine ph3 trial #esmo12 $CELG
  17. Hidalgo: "nab-paclitaxel and gemcitabine show interesting clinical and tissue effects" #esmo12
  18. Hidalgo in Q&A: "what I hope is the combination will be approved based on a median OS in 10, 11 month range" $CELG #esmo12
  19. In future in pancreatic cancer I think we will see new chemos & new targeted agents, with careful pat selection based on biology #esmo12
  20. Abraxane will change standard of care if approved
  21. Abraxane will change the standard of care if approved for pancreatic cancer. If the data shows a doubling of survival time (or even longer) for patients with advanced disease, it will be a major breakthrough, and of sufficient magnitude to be considered for a plenary presentation at the ASCO annual meeting next year. It was exciting to be at this symposia and see a glimpse of the possible future.
  22. Update Sept 29: Abraxane data probably at ASCO GI meeting in early 2013
  23. Michel Ducreux (TH-302 discussant) tells #esmo12 that nab-paclitaxel (Abraxane) ph3 data will probably be at ASCO GI
  24. Update Nov 10: Celgene announces that Abraxane significantly increases overall survival in pancreatic cancer trial

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